Contamination Expert Blog

White paper: Discolouration and odour formation in radiation sterilised personal protective equipment

Written by Hannah Molemans | Dec 5, 2025 9:30:00 AM

Contamination control depends on the integrity of personal protective equipment (PPE). Radiation sterilisationis widely used to ensure PPE is free from microorganisms. But beyond sterility, changes in material properties such as discolouration and odour formation can influence operator perception, comfort, and compliance in cleanroom environments.

The impact of radiation on PPE

Polymers used in cleanroom PPE, like neoprene, polypropylene, polyethylene, nitrile, and latex, are susceptible to free radical reactions during radiation sterilisation. These reactions can lead to:

  • Discolouration, often yellowing or browning.
  • Odour formation, caused by volatile organic compounds (VOCs).

While these effects don’t necessarily compromise protective function, they can affect operator confidence and the perception of product quality.

Supported through research

Studies show that both gamma and X‑ray sterilisation have comparable microbicidal effectiveness, but they can trigger aesthetic changes in polymers. Research highlights explained in this newest white paper:

  • Colour shifts
  • Odour profiles
  • Toxicological risks and nuisance factors

Understanding these nuances is vital for contamination control experts. PPE selection should consider not only sterility assurance and regulatory compliance but also material behaviour under sterilisation to maintain operator comfort and workflow efficiency.

Optimising PPE selection

Contamination control in pharma and life sciences is about more than sterility—it’s about trust, usability, and sustainability. We invite you to explore the full article for deeper insights into how radiation sterilisation affects PPE and how to optimise your selection process.

Optimize your selection

We invite you to explore the full white paper for deeper insights into how radiation sterilisation affects PPE and how to optimise your selection process. The white paper aims to enhance your approach to selecting, validating, and managing cleanroom PPE, and ultimately, to strengthen your contamination control outcomes.

Let’s collaborate to create the best conditions for your products to flourish!